Tesamorelin

Tesamorelin is a stabilized 44-amino-acid GHRH analog. It binds the pituitary’s GHRH receptors, prompting increased synthesis and pulsatile release of your body’s own growth hormone — which raises hepatic IGF-1 and drives the axis’s anabolic and lipolytic effects. It restores a rhythm rather than replacing a hormone.

The active molecule is FDA-approved as Egrifta SV, for HIV-associated lipodystrophy (visceral-fat reduction). We prescribe it compounded and off-label for longevity and body-composition goals — which is a different use, and not itself FDA-approved. We say that plainly. It’s compounded by VialsRX, a state-licensed pharmacy; we never brand Trellis as the compounder or call the longevity use FDA-cleared.

Both are GHRH analogs that prompt your own GH, but tesamorelin has a longer half-life and produces a stronger, more predictable pulse — and its active is FDA-approved as a finished drug for a specific indication, which sermorelin’s is not. Those are the reasons we moved the growth-hormone-axis protocol to tesamorelin.

No. Exogenous HGH replaces the hormone directly. Tesamorelin stimulates your pituitary to produce its own GH in natural, pulsatile rhythm — a physiological signal, not a replacement. That distinction is the whole point of the mechanism.

It varies, which is why candidacy and progress are lab-driven here. Members commonly notice recovery and sleep quality first, with body-composition and IGF-1 changes tracked against a baseline and a re-test. Your clinician designs the protocol to move specific markers and adjusts from the trend.

Common side effects are mild and transient — injection-site reactions, joint aches (arthralgia), and fluid retention (edema). Tesamorelin can raise blood sugar, so clinicians monitor HbA1c. It is not appropriate in active malignancy, pituitary disease, pregnancy, or uncontrolled diabetes. Your clinician reviews your full health context before approving anything.

Yes — and here it’s genuinely load-bearing. An IGF-1 and metabolic baseline confirms whether you’re a candidate, and follow-up labs (including HbA1c) drive monitoring. The free Vitality Lab Kit is how we confirm candidacy before prescribing, rather than assuming it.

Tesamorelin protocols are HSA/FSA-eligible for most US plans, and we provide an itemized superbill on request. Longevity and peptide protocols generally aren’t billed to insurance — you pay per protocol, monthly, and most members offset the cost with HSA/FSA dollars.

It’s compounded in a US state-licensed, cGMP-compliant pharmacy (VialsRX, Houston, TX) and quality-tested every batch for potency (±10%), sterility (USP <797>), pH, and endotoxicity (USP <85>) before it ships.

Often, yes — NAD⁺ is a common pairing as the cellular-energy floor beneath the GH axis. It depends on your full medication and supplement list, which your clinician reviews during intake. Flag everything you take so they can confirm there are no interactions.

No membership and no tiers. Plans differ only by duration — monthly, 3-month, or 6-month — and you can pause or stop anytime. Longer plans simply lower your per-month cost.

GHRH peptides act on the growth-hormone axis and are relevant to anti-doping rules. If you’re a competitive athlete subject to WADA or similar testing, flag it during intake — this is an honest heads-up, not medical or eligibility advice, and your clinician will factor it in.