Typical at-home subcutaneous NAD+ doses are 50–100 mg given one to three times per week, usually started low and titrated up by about 20 mg every one to two weeks to stay comfortable. There’s no single FDA-approved dose — NAD+ is compounded and dosed per patient — so the right amount depends on your goals, tolerance, and a clinician’s guidance (Empower Pharmacy; MediveraRx). On timing, most people inject in the morning, because some report mild stimulation that can disrupt sleep if dosed late.
How much NAD+ should you take?
Common subcutaneous protocols use 50–100 mg per injection, one to three times weekly, with many people landing around 100 mg as a maintenance dose (RWA Center; Empower Pharmacy). Intramuscular doses run a little higher (100–200 mg) and absorb faster, which is why they’re more likely to cause a brief flushed feeling.
There are no officially approved dosages, so these are common clinical ranges rather than fixed rules (MediveraRx). For at-home use, providers often advise keeping cumulative weekly intake modest unless there’s a specific indication, and adjusting based on how you respond.
Why start low and titrate up?
Starting at a low dose and increasing gradually — roughly 20 mg every one to two weeks — lets most people reach an effective dose while avoiding the headaches, nausea, and flushing that come with too much, too fast (Empower Pharmacy). The goal isn’t the highest dose possible; it’s the dose that raises your NAD+ availability enough to support your goals while staying comfortable and sustainable (RWA Center).
Injecting slowly matters as much as the number. Because NAD+ side effects are largely rate-dependent, a slow subcutaneous push is more comfortable than a rapid one (Perfect B).
Morning vs. afternoon: when should you inject NAD+?
Most people inject NAD+ in the morning. Some users report a mild energizing effect, and a subset find that mid-day or evening dosing leaves them too alert at bedtime — a recurring question in user communities is whether afternoon injections affect sleep. If you notice a mid-day lull after morning dosing, the usual adjustments are tweaking the dose, the day of the week, or the injection timing rather than abandoning the protocol.
There’s no universal “best time” established in trials — this is individual. The practical approach is to start in the morning, note how it affects your energy and sleep, and adjust with your clinician from there.
Dosing factors that change the right number
| Factor | Effect on dosing |
|---|---|
| Goals (energy vs. recovery) | Shifts target dose and frequency |
| Tolerance / side effects | Lower or slower titration if flushing/nausea appears |
| Route (SC vs. IM) | IM runs higher per dose, absorbs faster |
| Body response over time | Re-tested biomarkers guide adjustments |
Your dose isn’t a fixed prescription you set once — it’s calibrated to how your body and biomarkers respond, which is why monitoring matters.
NAD+ dosing and timing FAQ
How much NAD+ should I inject? Common at-home subcutaneous doses are 50–100 mg, one to three times weekly, often started low and increased by about 20 mg every one to two weeks. There’s no FDA-approved dose, so a clinician personalizes it to your goals and tolerance.
When is the best time to inject NAD+? Most people inject in the morning, since some report a mild energizing effect that can disrupt sleep if dosed late. The best time is individual — start in the morning and adjust based on your energy and sleep.
Why should I start with a low NAD+ dose? Starting low and titrating up gradually helps you reach an effective dose while avoiding flushing, nausea, and headache, which are usually caused by too much too quickly.
Does NAD+ affect sleep? It can. Some users find later-day dosing leaves them too alert at bedtime. If that happens, adjusting the dose or shifting injections earlier usually helps.
What’s the difference between subcutaneous and intramuscular NAD+ dosing? Subcutaneous doses are typically 50–100 mg and absorb gradually; intramuscular doses run higher (100–200 mg) and absorb faster, which can cause a brief flushed sensation.
Your dose should be calibrated to your goals and biomarkers, with a clinician. Start your free Vitality Assessment →